Nature Communications (Sep 2020)
A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis
- Tadasuke Tsukiyama,
- Juqi Zou,
- Jihoon Kim,
- Shohei Ogamino,
- Yuki Shino,
- Takamasa Masuda,
- Alessandra Merenda,
- Masaki Matsumoto,
- Yoichiro Fujioka,
- Tomonori Hirose,
- Sayuri Terai,
- Hidehisa Takahashi,
- Tohru Ishitani,
- Keiichi I. Nakayama,
- Yusuke Ohba,
- Bon-Kyoung Koo,
- Shigetsugu Hatakeyama
Affiliations
- Tadasuke Tsukiyama
- Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Juqi Zou
- Department of Homeostatic Regulation, Research Institute for Microbial Diseases, Osaka University
- Jihoon Kim
- Department of Genetics, University of Cambridge
- Shohei Ogamino
- Laboratory of Integrated Signaling Systems, Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma University
- Yuki Shino
- Faculty of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku
- Takamasa Masuda
- Division of Cell Regulation Systems, Medical Institute of Bioregulation, Kyushu University
- Alessandra Merenda
- Department of Genetics, University of Cambridge
- Masaki Matsumoto
- Division of Proteomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University
- Yoichiro Fujioka
- Department of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Tomonori Hirose
- Department of Molecular Biology, Yokohama City University Graduate School of Medical Science
- Sayuri Terai
- Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Hidehisa Takahashi
- Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Tohru Ishitani
- Department of Homeostatic Regulation, Research Institute for Microbial Diseases, Osaka University
- Keiichi I. Nakayama
- Division of Proteomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University
- Yusuke Ohba
- Department of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Bon-Kyoung Koo
- Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC)
- Shigetsugu Hatakeyama
- Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- DOI
- https://doi.org/10.1038/s41467-020-18257-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
RNF43 is frequently mutated in cancers and negatively regulates Wnt signalling. Here, the authors report that RNF43 phosphorylation at a serine triplet is required for the negative regulation of Wnt signalling and that the phosphorylation of RNF43 suppresses cancer-associated oncogenic RNF43 mutants.
