Vitamin D, men’s health and prostate (literature review)

Abstract

General and private questions of clinical endocrinology and pathophysiology of vitamin D disorders at men are considered in the literary review. The general part of the review is devoted the analysis not numerous while epidemiological and the clinical-experimental researches showing an important role of vitamin D deficiency as a factor of deterioration of modern men health from the point of view of increase at them cardiovascular and oncological risks, and also indicators of the general death rate. High frequency of vitamin D deficiency both in the world, and in population of the Russian men is shown. Laboratory criteria of various kinds of vitamin D disorders are resulted. Inflammatory and tumoral prostate diseases which are the most often meeting in andrological practice are considered as a private examples of a role of vitamin D and its disorders at men. Considering their high prevalence, as well as prevalence of vitamin D deficiency, in man’s population and a close connection with system hormonal-metabolic disorders (obesity, insulin resistance, androgen deficiency), it is possible to assume additional negative influence of vitamin D deficiency to initiation, clinical current and progressing both system disorders of hormonal-metabolic homeostasis, and prostate diseases too. The further development of vitamin D endocrinology within the limits of andrology can lead in the long term to working out new rational pharmacotherapeutical options for pathogenetic management of a prostate pathology.

Keywords

• vitamin D
• vitamin D deficiency
• prostate diseases
• chronic prostatitis
• benign prostatic hyperplasia
• prostate cancer