Japanese Dental Science Review (Nov 2019)

B cell dysregulation in primary Sjögren’s syndrome: A review

  • Hazim Mahmoud Ibrahem

DOI
https://doi.org/10.1016/j.jdsr.2019.09.006
Journal volume & issue
Vol. 55, no. 1
pp. 139 – 144

Abstract

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Primary Sjögren’s syndrome is a chronic autoimmune disorder of unknown etiology and is characterized by progressive focal lymphocytic infiltration of the lacrimal and salivary glands. Comparison of B cell subsets from the peripheral blood and salivary glands of patients with primary Sjögren’s syndrome and those from healthy individuals shows dysregulation and derangement of B cell subsets in both peripheral circulation and in inflamed glandular tissues. This dysregulation is expressed as a decrease in the percentage of CD27+ memory B cells in peripheral blood and an increase in the CD27+ memory B cells in the affected glands. Further, the overall percentage of long-lived autoantibodies-producing plasma cells within the affected glands is increased. In the last two decades, several studies have shown growing evidences that B cells play multiple roles in primary Sjögren’s syndrome pathophysiology, and that dysregulation of these cells may actually play a central role in the disease development. Keywords: B cells, Sjögren’s syndrome, Peripheral blood, Salivary gland, Germinal center, CD27