Nature Communications (Jun 2022)
Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation
- Nicole M. Revie,
- Kali R. Iyer,
- Michelle E. Maxson,
- Jiabao Zhang,
- Su Yan,
- Caroline M. Fernandes,
- Kirsten J. Meyer,
- Xuefei Chen,
- Iwona Skulska,
- Meea Fogal,
- Hiram Sanchez,
- Saif Hossain,
- Sheena Li,
- Yoko Yashiroda,
- Hiroyuki Hirano,
- Minoru Yoshida,
- Hiroyuki Osada,
- Charles Boone,
- Rebecca S. Shapiro,
- David R. Andes,
- Gerard D. Wright,
- Justin R. Nodwell,
- Maurizio Del Poeta,
- Martin D. Burke,
- Luke Whitesell,
- Nicole Robbins,
- Leah E. Cowen
Affiliations
- Nicole M. Revie
- Department of Molecular Genetics, University of Toronto
- Kali R. Iyer
- Department of Molecular Genetics, University of Toronto
- Michelle E. Maxson
- Program in Cell Biology, The Hospital for Sick Children
- Jiabao Zhang
- Department of Chemistry, Roger Adams Laboratory, University of Illinois at Urbana-Champaign
- Su Yan
- Department of Chemistry, Roger Adams Laboratory, University of Illinois at Urbana-Champaign
- Caroline M. Fernandes
- Department of Microbiology and Immunology, Stony Brook University
- Kirsten J. Meyer
- Department of Biochemistry, University of Toronto
- Xuefei Chen
- David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University
- Iwona Skulska
- Department of Molecular and Cellular Biology, University of Guelph
- Meea Fogal
- Department of Molecular and Cellular Biology, University of Guelph
- Hiram Sanchez
- Department of Medicine, University of Wisconsin School of Medicine and Public Health
- Saif Hossain
- Department of Molecular Genetics, University of Toronto
- Sheena Li
- Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research
- Yoko Yashiroda
- RIKEN Center for Sustainable Resource Science, Wako
- Hiroyuki Hirano
- RIKEN Center for Sustainable Resource Science, Wako
- Minoru Yoshida
- RIKEN Center for Sustainable Resource Science, Wako
- Hiroyuki Osada
- RIKEN Center for Sustainable Resource Science, Wako
- Charles Boone
- Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research
- Rebecca S. Shapiro
- Department of Molecular and Cellular Biology, University of Guelph
- David R. Andes
- Department of Medicine, University of Wisconsin School of Medicine and Public Health
- Gerard D. Wright
- David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University
- Justin R. Nodwell
- Department of Biochemistry, University of Toronto
- Maurizio Del Poeta
- Department of Microbiology and Immunology, Stony Brook University
- Martin D. Burke
- Department of Chemistry, Roger Adams Laboratory, University of Illinois at Urbana-Champaign
- Luke Whitesell
- Department of Molecular Genetics, University of Toronto
- Nicole Robbins
- Department of Molecular Genetics, University of Toronto
- Leah E. Cowen
- Department of Molecular Genetics, University of Toronto
- DOI
- https://doi.org/10.1038/s41467-022-31308-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
There is an urgent need for novel strategies to combat life-threatening fungal infections. Here, Revie et al. identify a compound that induces alterations in fungal membranes, synergizes with azole antifungals against the pathogen Candida albicans, and inhibits virulence traits and biofilm formation in animal models of infection.
