Nature Communications (Jul 2020)
Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target
- Joseph W. Franses,
- Julia Philipp,
- Pavlos Missios,
- Irun Bhan,
- Ann Liu,
- Chittampalli Yashaswini,
- Eric Tai,
- Huili Zhu,
- Matteo Ligorio,
- Benjamin Nicholson,
- Elizabeth M. Tassoni,
- Niyati Desai,
- Anupriya S. Kulkarni,
- Annamaria Szabolcs,
- Theodore S. Hong,
- Andrew S. Liss,
- Carlos Fernandez-del Castillo,
- David P. Ryan,
- Shyamala Maheswaran,
- Daniel A. Haber,
- George Q. Daley,
- David T. Ting
Affiliations
- Joseph W. Franses
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Julia Philipp
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Pavlos Missios
- Children’s Hospital Boston, Harvard Medical School
- Irun Bhan
- Massachusetts General Hospital Division of Gastroenterology, Harvard Medical School
- Ann Liu
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Chittampalli Yashaswini
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Eric Tai
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Huili Zhu
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Matteo Ligorio
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Benjamin Nicholson
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Elizabeth M. Tassoni
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Niyati Desai
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Anupriya S. Kulkarni
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Annamaria Szabolcs
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Theodore S. Hong
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Andrew S. Liss
- Massachusetts General Hospital Department of Surgery, Harvard Medical School
- Carlos Fernandez-del Castillo
- Massachusetts General Hospital Department of Surgery, Harvard Medical School
- David P. Ryan
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Shyamala Maheswaran
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Daniel A. Haber
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- George Q. Daley
- Children’s Hospital Boston, Harvard Medical School
- David T. Ting
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-020-17150-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Metastatic dissemination contributes to the lethality in pancreatic ductal adenocarcinoma (PDAC). Here, the authors perform RNA-sequencing on patient derived circulating tumor cells (CTCs) and identify three major CTC subgroups, and show the therapeutic potential of targeting LIN28B/let-7 pathway to halt cancer metastasis.
