Perioperative blood transfusion does not affect recurrence-free and overall survivals after curative resection for intrahepatic cholangiocarcinoma: a propensity score matching analysis
Pei-Yun Zhou,
Zheng Tang,
Wei-Ren Liu,
Meng-Xin Tian,
Lei Jin,
Xi-Fei Jiang,
Han Wang,
Chen-Yang Tao,
Zhen-Bin Ding,
Yuan-Fei Peng,
Shuang-Jian Qiu,
Zhi Dai,
Jian Zhou,
Jia Fan,
Ying-Hong Shi
Affiliations
Pei-Yun Zhou
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University
Zheng Tang
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University
Wei-Ren Liu
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University
Meng-Xin Tian
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University
Lei Jin
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University
Xi-Fei Jiang
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University
Han Wang
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University
Chen-Yang Tao
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University
Zhen-Bin Ding
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University
Yuan-Fei Peng
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University
Shuang-Jian Qiu
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University
Zhi Dai
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University
Jian Zhou
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University
Jia Fan
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University
Ying-Hong Shi
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University
Abstract Background Whether perioperative blood transfusions (PBTs) adversely influence oncological outcomes for intrahepatic cholangiocarcinoma (ICC) patients after curative resection remains undetermined. Methods Of the 605 patients who underwent curative liver resection for ICC between 2000 and 2012, 93 received PBT. We conducted Cox regression and variable selection logistic regression analyses to identify confounding factors of PBT. Propensity score matching (PSM) and Cox regression analyses were used to compare the overall survival (OS) and disease-free survival (DFS) between the patients with or without PBT. Results After exclusion, 93 eligible patients (15.4%) received PBT, compared with 512 (84.6%) who did not receive PBT; the groups were highly biased in terms of the propensity score (PS) analysis (0.096 ± 0.104 vs. 0.479 ± 0.372, p < 0.001). PBT was associated with an increased risk of OS (HR: 1.889, 95% CI: 1.446–2.468, p < 0.001) and DFS (HR: 1.589, 95% CI: 1.221–2.067, p < 0.001) in the entire cohort. After propensity score matching (PSM), no bias was observed between the groups (PS,0.136 ± 0.117 VS. 0.193 ± 0.167, p = 0.785). In the multivariate Cox analysis, PBT was not associated with increased risks of OS (HR: 1.172, 95% CI: 0.756–1.816, p = 0.479) and DFS (HR: 0.944, 95% CI: 0.608–1.466, p = 0.799). After propensity score adjustment, PBT was still not associated with OS or DFS after ICC curative resection. Conclusions The present study found that PBT did not affect DFS and OS after curative resection of ICC.