PLoS ONE (Jan 2021)

Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population

  • Youhei Yamada,
  • Haruki Nakamura,
  • Hiromasa Tsujiguchi,
  • Akinori Hara,
  • Sakae Miyagi,
  • Takayuki Kannon,
  • Takehiro Sato,
  • Kazuyoshi Hosomichi,
  • Thao Thi Thu Nguyen,
  • Yasuhiro Kambayashi,
  • Yukari Shimizu,
  • Kim Oanh Pham,
  • Keita Suzuki,
  • Fumihiko Suzuki,
  • Tomoko Kasahara,
  • Hirohito Tsuboi,
  • Atsushi Tajima,
  • Hiroyuki Nakamura

Journal volume & issue
Vol. 16, no. 8

Abstract

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A polymorphism in the ADRB3 gene (Trp64Arg) has been associated with obesity, insulin resistance, and hypertension. This cross-sectional study investigated the relationships among this polymorphism, hypertension, and insulin resistance values (HOMA-IR) in 719 Japanese subjects aged 40 years and older. The genotype frequencies of Trp64Trp (homozygous, wild), Trp64Arg (heterozygous, variant), and Arg64Arg (homozygous, variant) were 466 (65%), 233 (32%), and 20 (3%), respectively. Insulin resistance was associated with an increased risk of hypertension in a Japanese population. This relationship was dependent on the presence or absence of the Trp64Arg polymorphism (odds ratio, 2.054; confidence interval, 1.191 to 3.541; P value, 0.010). Therefore, the Trp64Arg polymorphism of ADRB3 was associated with hypertension and insulin resistance in a healthy Japanese population. This relationship, which was dependent on the polymorphism, may predict the development of hypertension and diabetes.