Serum levels of OPG, RANKL and RANKL/OPG ratios in newly-diagnosed patients with multiple myeloma. Clinical correlations

Abstract

Serum levels of OPG and RANKL and their clinical correlations were analyzed in 66 newly–diagnosed patients with multiple myeloma (MM). RANKL and RANKL/OPG ratios were significantly increased in advanced clinical stages and high grade myeloma bone disease (MBD), while OPG showed a tendency to decrease. Renal failure modified the expression of OPG. RANKL and RANKL/OPG ratios are informative markers for myeloma tumor burden and MBD.