Clinical Ophthalmology (Apr 2021)

Relationship Between Central Corneal Thickness and Ganglionic-Inner Plexiform Cell Layer and Retinal Nerve Fibre Layer Thickness in Normal Subjects

  • Al Saad M,
  • Shehadeh A,
  • Meqbil J,
  • Elubous K,
  • Qablawi M,
  • Abu-Yaghi NY

Journal volume & issue
Vol. Volume 15
pp. 1809 – 1812

Abstract

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Mouna Al Saad, Amin Shehadeh, Jehad Meqbil, Khaled Elubous, Mohammed Qablawi, Nakhleh Abu-Yaghi Department of Special Surgery/Ophthalmology Division, School of Medicine, The University of Jordan, Amman, JordanCorrespondence: Mouna Al SaadDepartment of Special Surgery/Ophthalmology Division, School of Medicine, The University of Jordan, Queen Rania Street, P.O Box 113301, Amman, 11942, JordanTel +962 797793018Email [email protected]: To determine the relationship between central corneal thickness (CCT), ganglionic cell-inner plexiform layer thickness and macular nerve fibre layer (RNFL) thickness as measured by optical coherence tomography in a cohort of healthy subjects.Methods: Sixty healthy eyes from 60 subjects were included in this study. All subjects had a standard slit-lamp examination and optical coherence tomography. Central corneal thickness was measured using the Optopol spectral domain optical coherence tomography (SD OCT) machine (version 7.2.0). A linear mixed effects model was used to assess the relationship between central corneal thickness (CCT) and ganglionic cell-inner plexiform layer thickness and macular retinal nerve fibre layer thickness (RNFL).Results: Sixty healthy eyes from 60 subjects were included in this study. The average age was 41.8 years (± 20.6 years). There were 22 males (37%) and 38 females (63%). The average central corneal thickness was 525.2 ± 35.1 μm (451– 601) μm. The average macular retinal nerve fiber layer thickness was 28.9 ± 2.5 μm (23– 38μm), and the average ganglionic cell-inner plexiform layer thickness was 88.6 ± 6.3 μm (75– 110 μm). We found no statistically significant relationship between central corneal thickness and ganglionic cell-inner plexiform layer thickness (p=0.983) nor with macular RNFL (p =0.285).Conclusion: In this cohort of healthy subjects, there was no statistically significant relationship between central corneal thickness and ganglionic cell-inner plexiform layer thickness or with macular retinal nerve fibre layer thickness.Keywords: central corneal thickness, ganglion cell layer, inner plexiform layer, optical coherence tomography

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