Efficacy of proton pump inhibitors combined with intensive diet intervention in treatment of laryngopharyngeal reflux disease

Abstract

Objective To compare the efficacy of proton pump inhibitors (PPI) combined with intensive diet intervention vs PPI alone in the treatment of laryngopharyngeal reflux disease (LPRD). Methods A total of 210 patients diagnosed with LPRD in our hospital during January 2017 and January 2018 were recruited in this study, and were divided into PPI with intensive diet intervention group (PPI+diet group, n=110) and PPI group (n=100). The PPI+diet group received standardized acid suppression therapy and intensified dietary intervention, while the PPI group only received standardized acid suppression therapy and standard diet. Both groups were treated for 12 weeks. Reflux symptom index (RSI) and reflux symptoms score (RFS) was used to evaluate the efficacy before and after treatment. Results There were no statistical differences in age, sex and RSI and RFS scores between the 2 groups. After 8 weeks of treatment, the RSI (P < 0.01) and RFS (P < 0.01) scores were significantly improved in both PPI plus diet group and PPI group. As compared with the PPI group, the PPI plus intensive diet group had lower RSI and RFS scores (P < 0.05), especially in improving the symptoms of throat clearing, postnasal drip, cough and heartburn, chest pain and coughing post-eating or lying down. For the overall effective rate, the effective rate in PPI plus diet group and PPI group was 73.07% and 70.21% after 8 weeks of treatment, and the effective rate was improved to 83.67% and 80.00% after 12 weeks, although there were no significant differences. Conclusion Compared with PPI alone, PPI combined with intensive diet intervention can more significantly improve the RSI and RFS scores of LPRD patients with higher overall efficiency.

Keywords

• aryngopharyngeal reflux
• proton pump inhibitors
• diet intervention
• treatment