Structural and dynamic mechanisms of GABAA receptor modulators with opposing activities

Shaotong Zhu; Akshay Sridhar; Jinfeng Teng; Rebecca J. Howard; Erik Lindahl; Ryan E. Hibbs

doi:10.1038/s41467-022-32212-4

Nature Communications (Aug 2022)

Structural and dynamic mechanisms of GABAA receptor modulators with opposing activities

Shaotong Zhu,
Akshay Sridhar,
Jinfeng Teng,
Rebecca J. Howard,
Erik Lindahl,
Ryan E. Hibbs

Affiliations

Shaotong Zhu: Departments of Neuroscience and Biophysics, University of Texas Southwestern Medical Center
Akshay Sridhar: Dept. of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology
Jinfeng Teng: Departments of Neuroscience and Biophysics, University of Texas Southwestern Medical Center
Rebecca J. Howard: Dept. of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University
Erik Lindahl: Dept. of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology
Ryan E. Hibbs: Departments of Neuroscience and Biophysics, University of Texas Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-022-32212-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

Read online

GABAA receptors are important targets for anxiety, sedation and anesthesia. Here, the authors present structures bound by zolpidem (Ambien), the most prescribed hypnotic in the US, and DMCM, a negative modulator, providing insights into receptor modulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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