The Effects of Enzalutamide Monotherapy on Multiparametric 3T MR Imaging in Prostate Cancer

Rosanne CV. Van der Roest; Petra J. van Houdt; Stijn WTPJ. Heijmink; Jeroen de Jong; André M. Bergman; Wilbert Zwart; Uulke A. van der Heide; Henk G. van der Poel

doi:10.1016/j.eucr.2016.04.010

Urology Case Reports (Jul 2016)

The Effects of Enzalutamide Monotherapy on Multiparametric 3T MR Imaging in Prostate Cancer

Rosanne CV. Van der Roest,
Petra J. van Houdt,
Stijn WTPJ. Heijmink,
Jeroen de Jong,
André M. Bergman,
Wilbert Zwart,
Uulke A. van der Heide,
Henk G. van der Poel

Affiliations

Rosanne CV. Van der Roest: Department of Urology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Petra J. van Houdt: Department of Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Stijn WTPJ. Heijmink: Department of Radiology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Jeroen de Jong: Department of Pathology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
André M. Bergman: Department of Medical Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Wilbert Zwart: Department of Molecular Pathology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Uulke A. van der Heide: Department of Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Henk G. van der Poel: Department of Urology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands

DOI: https://doi.org/10.1016/j.eucr.2016.04.010
Journal volume & issue: Vol. 7, no. C
pp. 67 – 69

Abstract

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The effects of enzalutamide monotherapy on prostate tumor downsizing and multiparametric MRI are currently unknown. Here we present the first case in literature of a patient with high-grade prostate cancer who underwent 3 months of neoadjuvant enzalutamide, for which the effects on mpMRI and histology were determined. Tumor size reduction and downstaging were noted. Neoadjuvant enzalutamide resulted in an increase in ADC value on the DWI-MRI sequences. Histological changes were also observed.

Published in Urology Case Reports

ISSN: 2214-4420 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the genitourinary system. Urology
Website: http://www.urologycasereports.com/

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