Nature Communications (May 2016)

The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory

  • Judith R. Reinhard,
  • Alexander Kriz,
  • Milos Galic,
  • Nico Angliker,
  • Mathieu Rajalu,
  • Kaspar E. Vogt,
  • Markus A. Ruegg

DOI
https://doi.org/10.1038/ncomms11613
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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Learning and memory depend on the structural and functional plasticity of synapses. Reinhard et al. show that the calcium sensor Copine-6 is required for memory, controls spine structure by regulating Rac signalling, and through its modulation of actin, supports hippocampal LTP.