Nature Communications (Jul 2021)
SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance
- Rémy Robinot,
- Mathieu Hubert,
- Guilherme Dias de Melo,
- Françoise Lazarini,
- Timothée Bruel,
- Nikaïa Smith,
- Sylvain Levallois,
- Florence Larrous,
- Julien Fernandes,
- Stacy Gellenoncourt,
- Stéphane Rigaud,
- Olivier Gorgette,
- Catherine Thouvenot,
- Céline Trébeau,
- Adeline Mallet,
- Guillaume Duménil,
- Samy Gobaa,
- Raphaël Etournay,
- Pierre-Marie Lledo,
- Marc Lecuit,
- Hervé Bourhy,
- Darragh Duffy,
- Vincent Michel,
- Olivier Schwartz,
- Lisa A. Chakrabarti
Affiliations
- Rémy Robinot
- Virus & Immunity Unit, Department of Virology, Institut Pasteur
- Mathieu Hubert
- Virus & Immunity Unit, Department of Virology, Institut Pasteur
- Guilherme Dias de Melo
- Lyssavirus Epidemiology and Neuropathology Unit, Institut Pasteur
- Françoise Lazarini
- Perception and Memory Unit, Institut Pasteur
- Timothée Bruel
- Virus & Immunity Unit, Department of Virology, Institut Pasteur
- Nikaïa Smith
- Translational Immunology Lab, Department of Immunology, Institut Pasteur
- Sylvain Levallois
- Biology of Infection Unit, Institut Pasteur
- Florence Larrous
- Lyssavirus Epidemiology and Neuropathology Unit, Institut Pasteur
- Julien Fernandes
- UtechS Photonics BioImaging, C2RT, Institut Pasteur
- Stacy Gellenoncourt
- Virus & Immunity Unit, Department of Virology, Institut Pasteur
- Stéphane Rigaud
- Image Analysis Hub, C2RT, Institut Pasteur
- Olivier Gorgette
- UtechS Ultrastructural BioImaging UBI, C2RT, Institut Pasteur
- Catherine Thouvenot
- UtechS Ultrastructural BioImaging UBI, C2RT, Institut Pasteur
- Céline Trébeau
- Institut de l’Audition, Institut Pasteur, INSERM
- Adeline Mallet
- UtechS Ultrastructural BioImaging UBI, C2RT, Institut Pasteur
- Guillaume Duménil
- UtechS Ultrastructural BioImaging UBI, C2RT, Institut Pasteur
- Samy Gobaa
- Biomaterials and Microfluidics Core Facility, Institut Pasteur
- Raphaël Etournay
- Institut de l’Audition, Institut Pasteur, INSERM
- Pierre-Marie Lledo
- Perception and Memory Unit, Institut Pasteur
- Marc Lecuit
- Biology of Infection Unit, Institut Pasteur
- Hervé Bourhy
- Lyssavirus Epidemiology and Neuropathology Unit, Institut Pasteur
- Darragh Duffy
- Translational Immunology Lab, Department of Immunology, Institut Pasteur
- Vincent Michel
- Institut de l’Audition, Institut Pasteur, INSERM
- Olivier Schwartz
- Virus & Immunity Unit, Department of Virology, Institut Pasteur
- Lisa A. Chakrabarti
- Virus & Immunity Unit, Department of Virology, Institut Pasteur
- DOI
- https://doi.org/10.1038/s41467-021-24521-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
SARS-CoV-2 infection damages the airways. Here the authors show that SARS-CoV-2 infection induces the rapid loss of airway motile cilia, resulting in altered cilia clearance function. Cilia loss is preceded by reduced expression of the ciliogenesis regulator Foxj1.
