LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells

S. S. Höpner; Ana Raykova; R. Radpour; M. A. Amrein; D. Koller; G. M. Baerlocher; C. Riether; A. F. Ochsenbein

doi:10.1038/s41467-021-21317-x

Nature Communications (Feb 2021)

LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells

S. S. Höpner,
Ana Raykova,
R. Radpour,
M. A. Amrein,
D. Koller,
G. M. Baerlocher,
C. Riether,
A. F. Ochsenbein

Affiliations

S. S. Höpner: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern
Ana Raykova: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern
R. Radpour: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern
M. A. Amrein: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern
D. Koller: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern
G. M. Baerlocher: Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern
C. Riether: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern
A. F. Ochsenbein: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern

DOI: https://doi.org/10.1038/s41467-021-21317-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Regulation of self-renewal is critical during steady state and stress in haematpoietic stem cells (HSCs), and underlies leukaemia pathology. Here, the authors show that LIGHT and its receptor LTβR promote quiescence and self-renewal of HSCs and that LTβR deficiency promotes survival in a mouse leukaemia model.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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