Linseed intake associated with mediterranean diet improves hyperglycemia and blood pressure in west algerian patients with metabolic syndrome

Abstract

Introduction. Linseed grains are vegetable molecules with strong antioxidant effect, whith reduced risk for developing high blood pressure (HBP) and type 2 diabetes (T2D). Moreover, by their richness in alpha-linoleic acid, the precursor of Omega-3, linseed grains allow a low level in plasma total cholesterol (TC) and triglycerides (TG). Objective. To evaluate the effect of daily consumption of linseed grains associated with the Mediterranean diet (MD) on hyperglycemia and hypertension in patients with metabolic syndrome (MS). Population and Methods. Thirty six patients with MS and 18 witnesses were recruited. Patients followed the MD for 3 months with linseed supplementation. Anthropometric parameters, blood pressure and glucose homeostasis were determined before and after 3 months of the study. Results. Patients presented obesity and altered anthropometric profile, hypertension, increased glucose, insulin, HbA1c, insulin resistance and hypertriglyceridemia, compared to controls. After 3 months follow-up, a reduction in total energy intake, carbohydrates, simple carbohydrates, animal proteins, saturated fatty acids (SFA), polyunsaturated FA, cholesterol, 6/3 ratio and increase in proteins, fats, complex carbohydrates, vegetable proteins, monounsaturated FA (MUFA) 3 fats and fibers, were noted. Moreover, weight loss, improvement of anthropometric parameters, reduction of hypertension, glucose (36%), insulin (22%), HbA1c (32%), increase in HOMA-IR (31%) and insulin were observed, compared to baseline. In parallel, a reduction of TC (28%) and triglycerides (28%) was noted. Conclusion. Linseed grains, in association with MD, induces antihypertensive and hypoglycemic effects in MS patients.

Keywords

• Metabolic syndrome
• Linseed grains
• Mediterranean diet
• Blood pressure
• glycemia
• HbA1c
• Insulin