Relationship between the Levels of lncRNA H19 in Plasma and Different Adipose Tissue Depots with Patients’ Response to Bariatric Surgery
Marina S. Artemyeva,
Ludmila B. Vasileva,
Yi Ma,
Kirill A. Kondratov,
Anton V. Fedorov,
Anna A. Kostareva,
Sofia E. Lapshina,
Anna D. Anopova,
Nikolai P. Likhonosov,
Alexander E. Neymark,
Alina Yu. Babenko,
Evgeny V. Shlyakhto
Affiliations
Marina S. Artemyeva
Federal State Budgetary Institution “V.A. Almazov National Medical Research Centre” of the Ministry of Health of the Russian Federation, 197341 Saint Petersburg, Russia
Ludmila B. Vasileva
Federal State Budgetary Institution “V.A. Almazov National Medical Research Centre” of the Ministry of Health of the Russian Federation, 197341 Saint Petersburg, Russia
Yi Ma
Federal State Budgetary Institution “V.A. Almazov National Medical Research Centre” of the Ministry of Health of the Russian Federation, 197341 Saint Petersburg, Russia
Kirill A. Kondratov
Federal State Budgetary Institution “V.A. Almazov National Medical Research Centre” of the Ministry of Health of the Russian Federation, 197341 Saint Petersburg, Russia
Anton V. Fedorov
Federal State Budgetary Institution “V.A. Almazov National Medical Research Centre” of the Ministry of Health of the Russian Federation, 197341 Saint Petersburg, Russia
Anna A. Kostareva
Federal State Budgetary Institution “V.A. Almazov National Medical Research Centre” of the Ministry of Health of the Russian Federation, 197341 Saint Petersburg, Russia
Sofia E. Lapshina
Federal State Budgetary Institution “V.A. Almazov National Medical Research Centre” of the Ministry of Health of the Russian Federation, 197341 Saint Petersburg, Russia
Anna D. Anopova
Federal State Budgetary Institution “V.A. Almazov National Medical Research Centre” of the Ministry of Health of the Russian Federation, 197341 Saint Petersburg, Russia
Nikolai P. Likhonosov
Federal State Budgetary Institution “V.A. Almazov National Medical Research Centre” of the Ministry of Health of the Russian Federation, 197341 Saint Petersburg, Russia
Alexander E. Neymark
Federal State Budgetary Institution “V.A. Almazov National Medical Research Centre” of the Ministry of Health of the Russian Federation, 197341 Saint Petersburg, Russia
Alina Yu. Babenko
Federal State Budgetary Institution “V.A. Almazov National Medical Research Centre” of the Ministry of Health of the Russian Federation, 197341 Saint Petersburg, Russia
Evgeny V. Shlyakhto
Federal State Budgetary Institution “V.A. Almazov National Medical Research Centre” of the Ministry of Health of the Russian Federation, 197341 Saint Petersburg, Russia
Bariatric surgery represents a widespread approach to treating morbid obesity. The search for biomarkers to identify patients to whom this type of treatment will be most effective is needed. Our aim was to characterize the relationship of levels of lncRNA H19 in plasma and different adipose tissue depots with patients’ response to bariatric surgery. The study includes control subjects, patients with obesity and patients with obesity accompanied by impaired carbohydrate metabolism (ICM). Quantitative analysis of lncRNA H19 levels has been performed using qPCR in plasma and subcutaneous (SAT) and visceral adipose tissue (VAT). Patients with obesity without ICM have higher levels of lncRNA H19 in VAT compared to SAT, and higher levels of lncRNA H19 in SAT compared to SAT of control individuals. One year after the intervention, levels of lncRNA H19 decreased in SAT of patients with obesity without ICM. The preoperative level of lncRNA H19 in VAT demonstrates a positive correlation with excess weight loss and a negative correlation with initial BMI. In conclusion, ICM affects expression of lncRNA H19 in SAT of patients with obesity. The preoperative level of lncRNA H19 in VAT can be used to predict excess weight loss in patients with obesity after bariatric surgery.
