Nature Communications (Jan 2023)
B cell analyses after SARS-CoV-2 mRNA third vaccination reveals a hybrid immunity like antibody response
- Emanuele Andreano,
- Ida Paciello,
- Giulio Pierleoni,
- Giulia Piccini,
- Valentina Abbiento,
- Giada Antonelli,
- Piero Pileri,
- Noemi Manganaro,
- Elisa Pantano,
- Giuseppe Maccari,
- Silvia Marchese,
- Lorena Donnici,
- Linda Benincasa,
- Ginevra Giglioli,
- Margherita Leonardi,
- Concetta De Santi,
- Massimiliano Fabbiani,
- Ilaria Rancan,
- Mario Tumbarello,
- Francesca Montagnani,
- Claudia Sala,
- Duccio Medini,
- Raffaele De Francesco,
- Emanuele Montomoli,
- Rino Rappuoli
Affiliations
- Emanuele Andreano
- Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences
- Ida Paciello
- Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences
- Giulio Pierleoni
- VisMederi Research S.r.l.
- Giulia Piccini
- VisMederi S.r.l
- Valentina Abbiento
- Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences
- Giada Antonelli
- Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences
- Piero Pileri
- Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences
- Noemi Manganaro
- Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences
- Elisa Pantano
- Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences
- Giuseppe Maccari
- Data Science for Health (DaScH) Lab, Fondazione Toscana Life Sciences
- Silvia Marchese
- Department of Pharmacological and Biomolecular Sciences DiSFeB, University of Milan
- Lorena Donnici
- INGM, Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”
- Linda Benincasa
- VisMederi Research S.r.l.
- Ginevra Giglioli
- VisMederi Research S.r.l.
- Margherita Leonardi
- VisMederi Research S.r.l.
- Concetta De Santi
- Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences
- Massimiliano Fabbiani
- Department of Medical Sciences, Infectious and Tropical Diseases Unit, Siena University Hospital
- Ilaria Rancan
- Department of Medical Sciences, Infectious and Tropical Diseases Unit, Siena University Hospital
- Mario Tumbarello
- Department of Medical Sciences, Infectious and Tropical Diseases Unit, Siena University Hospital
- Francesca Montagnani
- Department of Medical Sciences, Infectious and Tropical Diseases Unit, Siena University Hospital
- Claudia Sala
- Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences
- Duccio Medini
- Data Science for Health (DaScH) Lab, Fondazione Toscana Life Sciences
- Raffaele De Francesco
- Department of Pharmacological and Biomolecular Sciences DiSFeB, University of Milan
- Emanuele Montomoli
- VisMederi Research S.r.l.
- Rino Rappuoli
- Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences
- DOI
- https://doi.org/10.1038/s41467-022-35781-6
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 9
Abstract
SARS-CoV-2 vaccines and infection induce antibody responses but the evolution of subsequent variants has resulted in the development of escape mutants. Here the authors characterise, at single cell level, the antibody response in donors after a third dose of SARS-CoV-2 mRNA vaccination and show difference in breadth, neutralisation and molecular signature according to the vaccination regimen used.
