MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis

Mary P. LaPierre; Katherine Lawler; Svenja Godbersen; I. Sadaf Farooqi; Markus Stoffel

doi:10.1038/s41467-022-33367-w

Nature Communications (Sep 2022)

MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis

Mary P. LaPierre,
Katherine Lawler,
Svenja Godbersen,
I. Sadaf Farooqi,
Markus Stoffel

Affiliations

Mary P. LaPierre: Institute of Molecular Health Sciences, ETH Zürich
Katherine Lawler: University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
Svenja Godbersen: Institute of Molecular Health Sciences, ETH Zürich
I. Sadaf Farooqi: University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
Markus Stoffel: Institute of Molecular Health Sciences, ETH Zürich

DOI: https://doi.org/10.1038/s41467-022-33367-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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The hypothalamus controls systemic energy homeostasis. Here, the authors show that loss of microRNA-7 in hypothalamic neurons causes obesity, increased growth and endocrine dysfunction in mice, and report genetic evidence that links microRNA-7 to height and adiposity in humans.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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