Patient Preference and Adherence (Nov 2021)
Between Curing and Torturing: Burden of Adverse Reaction in Drug-Resistant Tuberculosis Therapy
Abstract
Yudisia Ausi,1,2 Prayudi Santoso,3 Deni Kurniadi Sunjaya,4 Melisa Intan Barliana1,5 1Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia; 2Master Program in Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia; 3Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; 4Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; 5Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, IndonesiaCorrespondence: Melisa Intan BarlianaDepartment of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM. 21, Jatinangor, Bandung, Indonesia, 45363 Email [email protected]: Drug-resistant tuberculosis (DR-TB) requires prolonged and complex therapy which is associated with several adverse drug reactions (ADR). The burden of ADR can affect the quality of life (QoL) of patients that consists of physical, mental, and social well-being, and influences the beliefs and behaviors of patient related to treatment. This article reviews the burden of ADR and its association with QoL and adherence. We used PubMed to retrieve the relevant original research articles written in English from 2011 to 2021. We combined the following keywords: “tuberculosis,” “Drug-resistant tuberculosis,” “Side Effect,” “Adverse Drug Reactions,” “Adverse Event,” “Quality of Life,” “Adherence,” “Non-adherence,” “Default,” and “Loss to follow-up.” Article selection process was unsystematic. We included 12 relevant main articles and summarized into two main topics, namely, 1) ADR and QoL (3 articles), and 2) ADR and therapy adherence (9 articles). The result showed that patients with ADR tend to have low QoL, even in the end of treatment. Although it was torturing, the presence of ADR does not always result in non-adherence. It is probably because the perception about the benefit of the treatment dominates the perceived barrier. In conclusion, burden of ADR generally tends to degrade QoL of patients and potentially influence the adherence. A comprehensive support from family, community, and healthcare provider is required to help patients in coping with the burden of ADR. Nevertheless, the regimen safety and efficacy improvement are highly needed.Keywords: drug-resistant tuberculosis, adverse drug reaction, quality of life, adherence
