Clinical characteristics and prognostic characterization of endometrial carcinoma: a comparative analysis of molecular typing protocols

Zihui Yang; Xi Yang; Xinyu Liu; Ke Ma; Yi-Ting Meng; Hong-Fang Yin; Jia Wen; Jiang-Hui Yang; Zeng Zhen; Zong-Hao Feng; Qin-Ping Liao

doi:10.1186/s12885-023-10706-8

BMC Cancer (Mar 2023)

Clinical characteristics and prognostic characterization of endometrial carcinoma: a comparative analysis of molecular typing protocols

Zihui Yang,
Xi Yang,
Xinyu Liu,
Ke Ma,
Yi-Ting Meng,
Hong-Fang Yin,
Jia Wen,
Jiang-Hui Yang,
Zeng Zhen,
Zong-Hao Feng,
Qin-Ping Liao

Affiliations

Zihui Yang: Department of Obstetrics and Gynecology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University
Xi Yang: Department of Obstetrics and Gynecology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University
Xinyu Liu: Department of Reproductive Medicine, Shenyang 204 Hospital
Ke Ma: Department of Obstetrics and Gynecology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University
Yi-Ting Meng: Department of Pathology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University
Hong-Fang Yin: Department of Pathology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University
Jia Wen: Department of Obstetrics and Gynecology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University
Jiang-Hui Yang: Department of Pathology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University
Zeng Zhen: Department of Obstetrics and Gynecology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University
Zong-Hao Feng: Department of Obstetrics and Gynecology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University
Qin-Ping Liao: Department of Obstetrics and Gynecology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University

DOI: https://doi.org/10.1186/s12885-023-10706-8
Journal volume & issue: Vol. 23, no. 1
pp. 1 – 13

Abstract

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Highlights TCGA molecular classification has advantages over ProMisE classification for accurate diagnosis of endometrial carcinoma. Comparison among the four TCGA types (POLE, Low-CN, High-CN, and MSI-H) and age was statistically significant. Patients with POLE mutations and low-CN had higher PFS and overall survival, whereas those with high-CN had the lowest overall survival periods.

Published in BMC Cancer

ISSN: 1471-2407 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://bmccancer.biomedcentral.com

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Abstract

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