Application of Ic-VEP in diagnosis of early and middle stage glaucoma

Abstract

AIM: To study the sensitivity and specificity of Ic-VEP in diagnose of early and middle stage glaucoma. METHODS: All the participants included glaucoma patients and normal people came from Beijing Aier-Intech Eye Hospital from October 2014 to October 2016. All the participants performed slit lamp examination, fundus examination, Goldmann applanation tonometer, Humphery visual field examination, retinal nerve fiber layer(RNFL)thickness and macular ganglion cell complex(GCC)thickness examination and Ic-VEP. The sensitivity and specificity of Ic-VEP in diagnose of glaucoma were main results. RESULTS: The sensitivity and specificity of Ic-VEP in diagnose of glaucoma is 82% and 92% respectively. The area under ROC curve was 0.872. Consistency of Ic-VEP and GCC thickness in moderate glaucoma was good(Kappa value=0.75). CONCLUSION: Ic-VEP is a useful new method for the diagnosis of early and middle stage glaucoma.

Keywords

• visual evoked potential
• separation grating pattern
• glaucoma
• signal to noise ratio
• ganglion cell complex
• ganglion cell complex