Sensory gamma entrainment: Impact on amyloid protein and therapeutic mechanism

Jiaying Hu; Leyan Zheng; Ziyu Guan; Kexin Zhong; Fankai Huang; Qiankai Huang; Jing Yang; Weiyun Li; Shanshan Li

Brain Research Bulletin (Oct 2023)

Sensory gamma entrainment: Impact on amyloid protein and therapeutic mechanism

Jiaying Hu,
Leyan Zheng,
Ziyu Guan,
Kexin Zhong,
Fankai Huang,
Qiankai Huang,
Jing Yang,
Weiyun Li,
Shanshan Li

Affiliations

Jiaying Hu: Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China
Leyan Zheng: Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China
Ziyu Guan: Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China
Kexin Zhong: Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China
Fankai Huang: Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China
Qiankai Huang: Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China
Jing Yang: Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China; Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China
Weiyun Li: Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China; Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China
Shanshan Li: Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China; Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China; Corresponding author at: Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China.

Journal volume & issue: Vol. 202
p. 110750

Abstract

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The deposition of amyloid β peptide (Aβ) is one of the main pathological features of AD. The much-talked sensory gamma entrainment may be a new treatment for Aβ load. Here we reviewed the generation and clearance pathways of Aβ, aberrant gamma oscillation in AD, and the therapeutic effect of sensory gamma entrainment on AD. In addition, we discuss these results based on stimulus parameters and possible potential mechanisms. This provides the support for sensory gamma entrainment targeting Aβ to improve AD.

Published in Brain Research Bulletin

ISSN: 1873-2747 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.sciencedirect.com/journal/brain-research-bulletin

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Abstract

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