Nature Communications (Nov 2018)
Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
- Manasi Ratnaparkhe,
- John K. L. Wong,
- Pei-Chi Wei,
- Mario Hlevnjak,
- Thorsten Kolb,
- Milena Simovic,
- Daniel Haag,
- Yashna Paul,
- Frauke Devens,
- Paul Northcott,
- David T. W. Jones,
- Marcel Kool,
- Anna Jauch,
- Agata Pastorczak,
- Wojciech Mlynarski,
- Andrey Korshunov,
- Rajiv Kumar,
- Susanna M. Downing,
- Stefan M. Pfister,
- Marc Zapatka,
- Peter J. McKinnon,
- Frederick W. Alt,
- Peter Lichter,
- Aurélie Ernst
Affiliations
- Manasi Ratnaparkhe
- Division of Molecular Genetics, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ); Faculty of Biosciences, Heidelberg University Germany
- John K. L. Wong
- Division of Molecular Genetics, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
- Pei-Chi Wei
- Boston Children’s Hospital, Howard Hughes Medical Institute and Department of Genetics, Harvard Medical School
- Mario Hlevnjak
- Division of Molecular Genetics, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
- Thorsten Kolb
- Division of Molecular Genetics, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
- Milena Simovic
- Division of Molecular Genetics, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ); Faculty of Biosciences, Heidelberg University Germany
- Daniel Haag
- Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
- Yashna Paul
- Division of Molecular Genetics, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
- Frauke Devens
- Division of Molecular Genetics, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
- Paul Northcott
- Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ)
- David T. W. Jones
- Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
- Marcel Kool
- Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
- Anna Jauch
- Institute of Human Genetics, University of Heidelberg
- Agata Pastorczak
- Department of Pediatrics, Oncology, Hematology and Diabetology, Medical University of Lodz
- Wojciech Mlynarski
- Department of Pediatrics, Oncology, Hematology and Diabetology, Medical University of Lodz
- Andrey Korshunov
- Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Department of Neuropathology, Heidelberg University Hospital and German Cancer Consortium (DKTK)
- Rajiv Kumar
- Division of Molecular Genetic Epidemiology; German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center
- Susanna M. Downing
- Department of Genetics, St. Jude Children’s Research Hospital
- Stefan M. Pfister
- Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
- Marc Zapatka
- Division of Molecular Genetics, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
- Peter J. McKinnon
- Department of Genetics, St. Jude Children’s Research Hospital
- Frederick W. Alt
- Boston Children’s Hospital, Howard Hughes Medical Institute and Department of Genetics, Harvard Medical School
- Peter Lichter
- Division of Molecular Genetics, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
- Aurélie Ernst
- Division of Molecular Genetics, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
- DOI
- https://doi.org/10.1038/s41467-018-06925-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Chromothripsis and chromoanasynthesis lead to locally clustered rearrangements affecting one or a few chromosomes, but their impact on cancer development and progression is unclear. Here the authors analyse the role of DNA repair factors in brain tumors by whole-genome sequencing of tumors from mouse models of medulloblastoma or high grade gliomas.
