NEUROTOXICITY OF OCHRATOXIN A IN JAPANESIE QUAIL - HISTOLOGICAL AND ULTRASTRUCTURAL OBSERVATIONS

Abstract

Ochratoxin A was experimentally fed to Japanese quails and the histologic and ultrastructured charges were studied. Histologic changes included engorged blood vessels with swollen and vacuolated endothelim Focal oedema in brain with pyknosis and k:tryorrhexis. Ultrastructrally brain tissue showed vacuolation and fragmentation of perineuronal elements. Cytoplasm of neurons showed mild organellar changes