Use of anti-adhesion gels for intrauterine surgery

Abstract

Use of anti-adhesion gels for intrauterine surgery Ju.E. Dobrokhotova, I.I. Grishin, A.I. Grishin, V.I. Кomagorov Pirogov Russian National Research Medical University, Moscow, Russian Federation Any surgical intervention on pelvic organs leads to adhesion formation. Intrauterine synechiae are formed between opposite walls of a uterus after traumatizing the endometrium due to a surgical abortion procedure, use intrauterine contraceptives, a separate diagnostic curettage of the walls of a uterine cavity and cervical canal, in a uterine bleeding, polyps or endometrial hyperplasia, hysteroresectoscopy. As a result of the adhesion formation, Asherman syndrome develops, in which endometrial dysfunction is observed. The article gives an overview of literature data on research aimed at reducing adhesion development. To avoid a risk of the adhesion development, use of anti-adhesion barriers is necessary. The most effective anti-adhesion medications in obstetrics and gynecology are gels based on hyaluronic acid. Data of clinical recommendations that recommend use of the barrier anti-adhesion medications (gels), which include the hyaluronic acid, after any intrauterine procedures, in connection with existing evidences of adhesion process risk reduction in the uterine cavity, is presented. Clinical examples of successful Antiadhesin® gel use in patients with non-developing pregnancies in intrauterine interventions are presented. The use of anti-adhesion barriers is positively evaluated by doctors around the world in the prevention of adhesions, abortion, using various surgical methods of treatment. Key words: Asherman syndrome, gynecologic surgery, infertility, hyaluronic acid, adhesion process, Antiadhesin®. For citation: Dobrokhotova Ju.E., Grishin I.I., Grishin A.I., Кomagorov V.I. A. et al. Use of anti-adhesion gels for intrauterine surgery. 2018;1(1):71–75.