Identification of chemoresistance-associated miRNAs in hypopharyngeal squamous cell carcinoma

Abstract

This study aimed to determine candidate miRNAs that could help to evaluate whether patients with hypopharyngeal squamous cell carcinoma (HSCC) would benefit from docetaxel, cisplatin, and 5-fluorouracil (TPF) induction chemotherapy. We downloaded the expression profiles of HSCC patients from the Gene Expression Omnibus database. miRNA profiles were analyzed via Principal Components Analysis (PCA), followed by Linear Discriminant Analysis (LDA). The Database Annotation for Visualization and Integrated Discovery tool was utilized for enrichment analysis; STRING and Cytoscape were used for network construction. We detected that hsa-miR-15b-5p, hsa-miR-93-5p, and hsa-miR-130a-3p might act as crucial regulators in chemoresistance of HSCC, and they may play as prognosticators and therapeutic targets in the future. [Med-Science 2020; 9(1.000): 160-3]

Keywords

• hscc
• chemoresistance
• component analysis
• functional enrichment analysis
• protein-protein interaction
• mirna-mrna regulatory network