Nature Communications (Oct 2018)
Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration
- Amine Meliani,
- Florence Boisgerault,
- Romain Hardet,
- Solenne Marmier,
- Fanny Collaud,
- Giuseppe Ronzitti,
- Christian Leborgne,
- Helena Costa Verdera,
- Marcelo Simon Sola,
- Severine Charles,
- Alban Vignaud,
- Laetitia van Wittenberghe,
- Giorgia Manni,
- Olivier Christophe,
- Francesca Fallarino,
- Christopher Roy,
- Alicia Michaud,
- Petr Ilyinskii,
- Takashi Kei Kishimoto,
- Federico Mingozzi
Affiliations
- Amine Meliani
- Sorbonne Université and INSERM U974
- Florence Boisgerault
- Genethon, UMR_S951 Inserm, Univ Evry, Université Paris Saclay, EPHE
- Romain Hardet
- Sorbonne Université and INSERM U974
- Solenne Marmier
- Sorbonne Université and INSERM U974
- Fanny Collaud
- Genethon, UMR_S951 Inserm, Univ Evry, Université Paris Saclay, EPHE
- Giuseppe Ronzitti
- Genethon, UMR_S951 Inserm, Univ Evry, Université Paris Saclay, EPHE
- Christian Leborgne
- Genethon, UMR_S951 Inserm, Univ Evry, Université Paris Saclay, EPHE
- Helena Costa Verdera
- Sorbonne Université and INSERM U974
- Marcelo Simon Sola
- Sorbonne Université and INSERM U974
- Severine Charles
- Genethon, UMR_S951 Inserm, Univ Evry, Université Paris Saclay, EPHE
- Alban Vignaud
- Genethon, UMR_S951 Inserm, Univ Evry, Université Paris Saclay, EPHE
- Laetitia van Wittenberghe
- Genethon, UMR_S951 Inserm, Univ Evry, Université Paris Saclay, EPHE
- Giorgia Manni
- Department of Experimental Medicine, University of Perugia
- Olivier Christophe
- INSERM U1176 and Unité Mixte de Recherche S1176, Université Paris-Sud
- Francesca Fallarino
- Department of Experimental Medicine, University of Perugia
- Christopher Roy
- Selecta Bioscience
- Alicia Michaud
- Selecta Bioscience
- Petr Ilyinskii
- Selecta Bioscience
- Takashi Kei Kishimoto
- Selecta Bioscience
- Federico Mingozzi
- Sorbonne Université and INSERM U974
- DOI
- https://doi.org/10.1038/s41467-018-06621-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Immunogenicity of AAV vectors renders repeated AAV dosing ineffective. Here the authors show that coadministration of nanoparticle-encapsulated rapamycin overcomes AAV immunogenicity through Treg induction, enabling efficient AAV redosing in mice and nonhuman primates.
