Nature Communications (May 2021)

Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer

  • Surashri Shinde-Jadhav,
  • Jose Joao Mansure,
  • Roni F. Rayes,
  • Gautier Marcq,
  • Mina Ayoub,
  • Rodrigo Skowronski,
  • Ronald Kool,
  • France Bourdeau,
  • Fadi Brimo,
  • Jonathan Spicer,
  • Wassim Kassouf

DOI
https://doi.org/10.1038/s41467-021-23086-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Radioresistance remains a challenge in the treatment of bladder cancer. In this study, the authors show in mice that radiation increases deposits of neutrophil extracellular traps (NETs) via a TLR4-dependent mechanism and that NETs-targeting strategies can improve the response to radiotherapy.