Is there a difference in the oral health status of healthy patients and those with inherited bleeding disorders? A systematic review and meta-analysis of case-control studies

Abstract

Objectives: The aim of this systematic review and meta-analysis of case-control studies was to identify the differences in oral health status between inherited bleeding disorders (IBDs) and healthy patients. Data: Only case-control studies were included in this review. The risk of bias was assessed using the NOS tool. The random-effects meta-analysis was performed for DMFT and Oral Health Index outcomes. Sources: Online databases were searched to identify studies reporting a comparison between IBDs oral health conditions (DMFT, Oral Health Index) and healthy patients. Study selection: Eight case-control studies were included. The majority of the included studies presented a high degree of methodological quality, while one presented a high risk of bias. A meta-analysis regarding the mean DMFT between IBDs and healthy patients reported that children and teenagers (p = 0.52; I² = 73%) or adult patients (p = 0.96, I²= 0) did not present statistically significant differences compared to control groups. The overall DMFT mean difference between IBDs and healthy patients was -0.18 (p = 0.64, I²=0). Conclusions: There are no differences considering the caries experience of inherited bleeding disorders compared to healthy patients. Clinical significance: The available evidence indicates that patients with inherited bleeding disorders present similar caries experience with healthy subjects.

Keywords

• inherited bleeding disorders
• caries
• DMFT
• case-control
• meta-analysis