Differential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics

Zhizeng Sun; Liya Hu; Banumathi Sankaran; B. V. Venkataram Prasad; Timothy Palzkill

doi:10.1038/s41467-018-06839-1

Nature Communications (Oct 2018)

Differential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics

Zhizeng Sun,
Liya Hu,
Banumathi Sankaran,
B. V. Venkataram Prasad,
Timothy Palzkill

Affiliations

Zhizeng Sun: Department of Pharmacology and Chemical Biology, Baylor College of Medicine
Liya Hu: Verna Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine
Banumathi Sankaran: Department of Molecular Biophysics and Integrated Bioimaging, Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory
B. V. Venkataram Prasad: Verna Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine
Timothy Palzkill: Department of Pharmacology and Chemical Biology, Baylor College of Medicine

DOI: https://doi.org/10.1038/s41467-018-06839-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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The NDM-1 β-lactamase confers resistance to most β-lactam antibiotics. By functional analysis of residues required for hydrolysis, Sun et al. reveal stringent sequence constraints for carbapenems, suggesting that specific combinations of NDM-1 inhibitors might help reducing resistance development

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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