Nature Communications (May 2020)

Lipid metabolism adaptations are reduced in human compared to murine Schwann cells following injury

  • Sofia Meyer zu Reckendorf,
  • Christine Brand,
  • Maria T. Pedro,
  • Jutta Hegler,
  • Corinna S. Schilling,
  • Raissa Lerner,
  • Laura Bindila,
  • Gregor Antoniadis,
  • Bernd Knöll

DOI
https://doi.org/10.1038/s41467-020-15915-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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The regeneration dynamics following peripheral nerve injury differs among species. Here, the authors compared transcriptomic and lipid metabolism changes in murine and human Schwann cells in vivo and ex vivo sural nerves, underlying their switch from myelinating to repair state following injury.