Molecular programming modulates hepatic lipid metabolism and adult metabolic risk in the offspring of obese mothers in a sex-specific manner

Christina Savva; Luisa A. Helguero; Marcela González-Granillo; Tânia Melo; Daniela Couto; Bo Angelin; Maria Rosário Domingues; Xidan Li; Claudia Kutter; Marion Korach-André

doi:10.1038/s42003-022-04022-3

Communications Biology (Oct 2022)

Molecular programming modulates hepatic lipid metabolism and adult metabolic risk in the offspring of obese mothers in a sex-specific manner

Christina Savva,
Luisa A. Helguero,
Marcela González-Granillo,
Tânia Melo,
Daniela Couto,
Bo Angelin,
Maria Rosário Domingues,
Xidan Li,
Claudia Kutter,
Marion Korach-André

Affiliations

Christina Savva: Department of Medicine, Cardiometabolic Unit and Integrated Cardio Metabolic Center, Karolinska Institute
Luisa A. Helguero: Institute of Biomedicine, Department of Medical Sciences, University of Aveiro
Marcela González-Granillo: Clinical Department of Endocrinology, Karolinska University Hospital Huddinge
Tânia Melo: Mass Spectrometry Centre, Department of Chemistry, University of Aveiro
Daniela Couto: Mass Spectrometry Centre, Department of Chemistry, University of Aveiro
Bo Angelin: Department of Medicine, Cardiometabolic Unit and Integrated Cardio Metabolic Center, Karolinska Institute
Maria Rosário Domingues: Mass Spectrometry Centre, Department of Chemistry, University of Aveiro
Xidan Li: Department of Medicine, Cardiometabolic Unit and Integrated Cardio Metabolic Center, Karolinska Institute
Claudia Kutter: Department of Microbiology, Tumor and Cell Biology, Science for Life Laboratory, Karolinska Institute
Marion Korach-André: Department of Medicine, Cardiometabolic Unit and Integrated Cardio Metabolic Center, Karolinska Institute

DOI: https://doi.org/10.1038/s42003-022-04022-3
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 17

Abstract

Read online

Sex and maternal obesity drive differently transcriptional and posttranscriptional regulation of major metabolic processes in the livers of female and male offspring, contributing to the sexual dimorphism in obesity-associated metabolic risk.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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