Antioxidants (Dec 2023)

The Role of Omega-3 in Attenuating Cardiac Remodeling and Heart Failure through the Oxidative Stress and Inflammation Pathways

  • Taline Lazzarin,
  • Danilo Martins,
  • Raquel S. Ballarin,
  • Marina G. Monte,
  • Marcos F. Minicucci,
  • Bertha F. Polegato,
  • Leonardo Zornoff

DOI
https://doi.org/10.3390/antiox12122067
Journal volume & issue
Vol. 12, no. 12
p. 2067

Abstract

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Cardiac remodeling is defined as molecular, cellular, and interstitial changes that manifest clinically as alterations in the size, shape, and function of the heart. Despite the pharmacological approaches, cardiac remodeling-related mortality rates remain high. Therefore, other therapeutic options are being increasingly studied. This review highlights the role of omega-3 as an adjunctive therapy to attenuate cardiac remodeling, with an emphasis on its antioxidant and anti-inflammatory actions.

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