Nature Communications (Sep 2021)
Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice
- Kanchan Bisht,
- Kenneth A. Okojie,
- Kaushik Sharma,
- Dennis H. Lentferink,
- Yu-Yo Sun,
- Hong-Ru Chen,
- Joseph O. Uweru,
- Saipranusha Amancherla,
- Zainab Calcuttawala,
- Antony Brayan Campos-Salazar,
- Bruce Corliss,
- Lara Jabbour,
- Jordan Benderoth,
- Bria Friestad,
- William A. Mills,
- Brant E. Isakson,
- Marie-Ève Tremblay,
- Chia-Yi Kuan,
- Ukpong B. Eyo
Affiliations
- Kanchan Bisht
- Department of Neuroscience, University of Virginia School of Medicine
- Kenneth A. Okojie
- Department of Neuroscience, University of Virginia School of Medicine
- Kaushik Sharma
- Department of Neuroscience, University of Virginia School of Medicine
- Dennis H. Lentferink
- Department of Neuroscience, University of Virginia School of Medicine
- Yu-Yo Sun
- Department of Neuroscience, University of Virginia School of Medicine
- Hong-Ru Chen
- Department of Neuroscience, University of Virginia School of Medicine
- Joseph O. Uweru
- Department of Neuroscience, University of Virginia School of Medicine
- Saipranusha Amancherla
- Department of Neuroscience, University of Virginia School of Medicine
- Zainab Calcuttawala
- Department of Neuroscience, University of Virginia School of Medicine
- Antony Brayan Campos-Salazar
- Department of Neuroscience, University of Virginia School of Medicine
- Bruce Corliss
- Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine
- Lara Jabbour
- Department of Neuroscience, University of Virginia School of Medicine
- Jordan Benderoth
- Department of Neuroscience, University of Virginia School of Medicine
- Bria Friestad
- Department of Neuroscience, University of Virginia School of Medicine
- William A. Mills
- Department of Neuroscience, University of Virginia School of Medicine
- Brant E. Isakson
- Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine
- Marie-Ève Tremblay
- Axe Neurosciences, Centre de recherche du CHU de Québec—Université Laval
- Chia-Yi Kuan
- Department of Neuroscience, University of Virginia School of Medicine
- Ukpong B. Eyo
- Department of Neuroscience, University of Virginia School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-25590-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Microglia are involved in debris clearance and synaptic pruning, among other processes. However, their direct interaction with the brain vasculature is less clear. Here, the authors show that capillary-associated microglia (CAMs) regulate vascular tone via PANX1-P2RY12 signalling.
