Effects of dihydroquercetin (DHQ “P” drops) in patients with previous transitory ischemic attacks associated with visual disorders

Abstract

A study involved 48 patients aged 33 to 79 years (average age – 62.6 years) with transient ischaemic attacks (TIA) and visual disorders, caused by cerebrovascular diseases (CVD). 24 patients from this group underwent treatment by GCP criteria and medical care standards in acute brain blood supply disturbances, TIA and therapy with dihydroquercetin “DHQ” “P” drops in the dose of 7 drops, twice a day for 10 days. All the patients had arterial hypertension (AH) stage 1-2. Control group consisted of 26 men and 20 women of comparable age (n=46; average age - 65.9 years) without cerebral ischemic events and visual disorders, findings regarding neurophysiological parameters of visually evoked potentials (VEP) and microcirculatory system state (MCS) were compared. Exclusion criteria: acute heart diseases, type 1-2 diabetes mellitus, glaucoma, secondary types of arterial hypertension and AH stage 3, hemorrhages and hereditary cerebrovascular syndromes. Assessment of the “DHQ” “P” influence on such microcirculatory system parameters (retinopathy components) as perivascular edema, perivascular microhemorrhages, arterio-venular coef­ficient was carried out by results of the fundus oculi vessels computed photometry and biological microscopy of the bulbar conjunctival vessel layers. According to the data regarding distribution of TIA amount, retinopathy stage and age, correlation of TIA was conditioned by retinopathy stage and other factors except of patients’ age. Patients with TIA associated with visual disorders in presence of CVD suffered from arterial hypertension in 72.98%. Stage 1-3 of retinopathy and optic disc functional disorders were all detected. In case of therapy with “DHQ “P” the positive changes in dynamic regarding capillary permeability restoration (in 71.43%±12,07, in retinopathy stage 1-2 in comparison with 38.46% without it) were established and less pronounced – in case of perivascular microhemorrhages. Such positive effects in the conducted study were characterized as tendency pattern (OR 2.87; p=0.08 for perivascular edema and OR 2.77; p=0.08 for microhemorrhages). The efficacy of therapy with “DHQ “P” in restoration of impaired optic disk functions according to the data of VEP (for NO component of VEP; OR 2.87; p=0.041) in the dosage of 7 drops twice a day during 10 days in case of CVD was revealed; this determines the perspective of further investigation of “DHQ “P” which contains dihydroquercetin.

Keywords

• dihydroquercetin, transient visual disorders, arterial hypertension, hypoxic-ischemic encephalopathy, transient ischemic attacks