Nature Communications (Apr 2016)

Insights into the activation mechanism of class I HDAC complexes by inositol phosphates

  • Peter J. Watson,
  • Christopher J. Millard,
  • Andrew M. Riley,
  • Naomi S. Robertson,
  • Lyndsey C. Wright,
  • Himali Y. Godage,
  • Shaun M. Cowley,
  • Andrew G. Jamieson,
  • Barry V. L. Potter,
  • John W. R. Schwabe

DOI
https://doi.org/10.1038/ncomms11262
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

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Class I histone deacetylase complexes can be activated by inositol phosphates. Here, the authors investigate the stereochemical requirements for activation; use the crystal structure to understand substrate recognition, and suggest an entropically driven mechanism of allostery.