Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
Chatmongkon Suwannapoom
Department of Fishery, School of Agriculture and Natural Resources, University of Phayao, Phayao 56000, Thailand
Ananya Dechakhamphu
Aesthetic Sciences and Health Program, Faculty of Thai Traditional and Alternative Medicine, Ubon Ratchathani Rajabhat University, Ubonratchathani 34000 Thailand; Thai Traditional Medicine Program, Faculty of Thai Traditional and Alternative Medicine, Ubon Ratchathani Rajabhat University, Ubonratchathani 34000 Thailand; Corresponding author.
The development of α-glucosidase inhibitors is essential for the prevention of type II diabetes. Previous research has investigated in vitro inhibition using isolated α-glucosidase, which may not accurately reflect physical processes. The method presented in this study aims to establish a rapid and inexpensive in vivo method to study the inhibition of α-glucosidase activity using Drosophila as a model organism. This method can be used to calculate the IC50 value of compounds of interest for inhibition of α-glucosidase activity. The method established in this study can be used for in vivo screening of anti-diabetic compounds. • A rapid and inexpensive in vivo method to study the inhibition of α-glucosidase activity. • This method can be used to calculate the IC50 value of compounds of interest for inhibition of α-glucosidase activity. • This is a useful method for in vivo screening of anti-diabetic compounds.
