Comparative immunogenicity and protective capacity of two Dengue-4 vaccine candidates based on P64k-envelope domain III
Abstract
In this work we compared, in the same immunization schedule in mice, two vaccine candidates against Dengue-4 based on the envelope protein domain III and the carrier P64k. Their molecular and antigenic features, immunogenicity and protective capacity in the viral encephalitis murine model are assessed. Our study endorses the strategy of using both sites of inclusion within the same P64k molecule, in order to enhance the immunogenicity of protein fragments.
