mSystems
(Oct 2021)
Plasmids Shape the Current Prevalence of
<i>tmexCD1-toprJ1</i>
among Klebsiella pneumoniae in Food Production Chains
Kai Peng,
Qian Wang,
Yi Yin,
Yan Li,
Yuan Liu,
Mianzhi Wang,
ShangShang Qin,
Zhiqiang Wang,
Ruichao Li
Affiliations
Kai Peng
College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China
Qian Wang
College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China
Yi Yin
College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China
Yan Li
College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China
Yuan Liu
ORCiD College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China
Mianzhi Wang
College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China
ShangShang Qin
ORCiD School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan Province, People’s Republic of China
Zhiqiang Wang
College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China
Ruichao Li
ORCiD College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China
DOI
https://doi.org/10.1128/mSystems.00702-21
Journal volume & issue
Vol. 6,
no. 5
Abstract
Read online
Tigecycline, the first member of the glycylcycline class of antibacterial agents, is frequently used to treat complicated infections caused by multidrug-resistant Gram-positive and Gram-negative bacteria. The emergence of a novel plasmid-mediated efflux pump, TmexCD1-ToprJ1, conferring resistance to multiple antimicrobials, including tigecycline, poses a huge risk to human health.
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