Nature Communications (Feb 2021)
Non-CG methylation and multiple histone profiles associate child abuse with immune and small GTPase dysregulation
- Pierre-Eric Lutz,
- Marc-Aurèle Chay,
- Alain Pacis,
- Gary G. Chen,
- Zahia Aouabed,
- Elisabetta Maffioletti,
- Jean-François Théroux,
- Jean-Christophe Grenier,
- Jennie Yang,
- Maria Aguirre,
- Carl Ernst,
- Adriana Redensek,
- Léon C. van Kempen,
- Ipek Yalcin,
- Tony Kwan,
- Naguib Mechawar,
- Tomi Pastinen,
- Gustavo Turecki
Affiliations
- Pierre-Eric Lutz
- McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
- Marc-Aurèle Chay
- McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
- Alain Pacis
- Department of Genetics, CHU Sainte-Justine Research Center
- Gary G. Chen
- McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
- Zahia Aouabed
- McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
- Elisabetta Maffioletti
- Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli
- Jean-François Théroux
- McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
- Jean-Christophe Grenier
- Department of Genetics, CHU Sainte-Justine Research Center
- Jennie Yang
- McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
- Maria Aguirre
- Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital, McGill University
- Carl Ernst
- McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
- Adriana Redensek
- Department of Human Genetics, McGill University
- Léon C. van Kempen
- Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital, McGill University
- Ipek Yalcin
- Centre National de la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg
- Tony Kwan
- Department of Human Genetics, McGill University
- Naguib Mechawar
- McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
- Tomi Pastinen
- Department of Human Genetics, McGill University
- Gustavo Turecki
- McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
- DOI
- https://doi.org/10.1038/s41467-021-21365-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Early-life adversity is thought to increase the risk of psychopathology through epigenetic mechanisms. Here, the authors profile 6 histone marks, chromatin states and DNA methylation in the lateral amygdala in subjects with a history of early-life adversity.
