Generation and characterization of human-derived iPSC lines from three pairs of monozygotic twins discordant for Parkinson's disease

Marija Dulovic-Mahlow; Agnieszka Lukomska; Sokhna Haissatou Diaw; Alexander Balck; Max Borsche; Karen Grütz; Insa Lenz; Franziska Rudolph; Katja Lohmann; Christine Klein; Philip Seibler

Stem Cell Research (Dec 2019)

Generation and characterization of human-derived iPSC lines from three pairs of monozygotic twins discordant for Parkinson's disease

Marija Dulovic-Mahlow,
Agnieszka Lukomska,
Sokhna Haissatou Diaw,
Alexander Balck,
Max Borsche,
Karen Grütz,
Insa Lenz,
Franziska Rudolph,
Katja Lohmann,
Christine Klein,
Philip Seibler

Affiliations

Marija Dulovic-Mahlow: Institute of Neurogenetics, University of Luebeck, Luebeck, Germany
Agnieszka Lukomska: Institute of Neurogenetics, University of Luebeck, Luebeck, Germany
Sokhna Haissatou Diaw: Institute of Neurogenetics, University of Luebeck, Luebeck, Germany
Alexander Balck: Institute of Neurogenetics, University of Luebeck, Luebeck, Germany
Max Borsche: Institute of Neurogenetics, University of Luebeck, Luebeck, Germany
Karen Grütz: Institute of Neurogenetics, University of Luebeck, Luebeck, Germany
Insa Lenz: Institute of Neurogenetics, University of Luebeck, Luebeck, Germany
Franziska Rudolph: Institute of Neurogenetics, University of Luebeck, Luebeck, Germany
Katja Lohmann: Institute of Neurogenetics, University of Luebeck, Luebeck, Germany
Christine Klein: Institute of Neurogenetics, University of Luebeck, Luebeck, Germany
Philip Seibler: Institute of Neurogenetics, University of Luebeck, Luebeck, Germany

Journal volume & issue: Vol. 41

Abstract

Read online

Despite a genetic component in the development of Parkinson’s disease (PD), monozygotic twin pairs often display discordance for PD. Here, we describe the generation of six human induced pluripotent stem cell (iPSC) lines from dermal fibroblasts of three pairs of monozygotic twins discordant for PD. We used non-integrating Sendai virus and the iPSC lines were comprehensively characterized. These lines provide a valuable resource for studying molecular differences between the affected and unaffected monozygotic twin and their response to genetic and non-genetic factors that might be involved in the development of PD. Keywords: Monozygotic twins discordant for Parkinson’s disease, Human-derived iPSC lines

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

About the journal