Nature Communications (Sep 2022)

The SARS-CoV-2 Omicron BA.1 spike G446S mutation potentiates antiviral T-cell recognition

  • Chihiro Motozono,
  • Mako Toyoda,
  • Toong Seng Tan,
  • Hiroshi Hamana,
  • Yoshihiko Goto,
  • Yoshiki Aritsu,
  • Yusuke Miyashita,
  • Hiroyuki Oshiumi,
  • Kimitoshi Nakamura,
  • Seiji Okada,
  • Keiko Udaka,
  • Mizuki Kitamatsu,
  • Hiroyuki Kishi,
  • Takamasa Ueno

DOI
https://doi.org/10.1038/s41467-022-33068-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 11

Abstract

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Mutations in the spike of SARS-CoV-2 can result in the escape of the neutralising antibody response but may retain susceptibility to the cellular immune response. Here the authors show the G446S mutation in the spike protein of Omicron BA.1 is associated with altered antigen presentation and potentiates activation of specific T cell immunity.