Сибирский онкологический журнал (Feb 2016)

EXPRESSION PROFILE OF MICRORNAS IN SQUAMOUS CELL HEAD AND NECK CARCINOMA

  • Yu. A. Veryaskina,
  • G. V. Kakurina,
  • E. S. Zhuravlev,
  • S. E. Titov,
  • I. V. Kondakova,
  • O. V. Cheremisina,
  • D. A. Shishkin,
  • I. F. Zhimulev,
  • E. L. Choynzonov,
  • N. N. Kolesnikov

Journal volume & issue
Vol. 0, no. 6
pp. 33 – 38

Abstract

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Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive disease with long asymptomatic course. New molecular prognostic markers are urgently needed to identify patients at high risk for developing lymph node metastasis. MicroRNAs (miRNAs) are a recently discovered class of small non-coding RNAs. Based on literature and our data, we have chosen 12 miRNAs (miRNA-21, -221, -222, -155, -205, -20a, -125b, -146b, -181b, -200a, -126, -451), involved in HNSCC carcinogenesis. Using real-time quantitative polymerase chain reaction analysis, we have shown a change in the expression miRNA in tumor tissue compared to unmodified tissue. Significant upregulation of five miRNAs: miRNA-21, -155, -181b, -126, -451 (p<0.05) has been shown in tumors. MiRNA-126 has been found to be highly expressed in metastasis tissue (p<0.05), and can be an important factor in understanding the processes of metastasis and development of a new prognostic marker.

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