Nature Communications (Mar 2023)
The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency
- Paraskevi Athanasouli,
- Martina Balli,
- Anchel De Jaime-Soguero,
- Annekatrien Boel,
- Sofia Papanikolaou,
- Bernard K. van der Veer,
- Adrian Janiszewski,
- Tijs Vanhessche,
- Annick Francis,
- Youssef El Laithy,
- Antonio Lo Nigro,
- Francesco Aulicino,
- Kian Peng Koh,
- Vincent Pasque,
- Maria Pia Cosma,
- Catherine Verfaillie,
- An Zwijsen,
- Björn Heindryckx,
- Christoforos Nikolaou,
- Frederic Lluis
Affiliations
- Paraskevi Athanasouli
- KU Leuven, Department of Development and Regeneration, Stem Cell Institute
- Martina Balli
- KU Leuven, Department of Development and Regeneration, Stem Cell Institute
- Anchel De Jaime-Soguero
- KU Leuven, Department of Development and Regeneration, Stem Cell Institute
- Annekatrien Boel
- Ghent-Fertility And Stem cell Team (G-FaST), Department for Reproductive Medicine, Department for Human Structure and Repair, Ghent University Hospital
- Sofia Papanikolaou
- Department of Rheumatology, Clinical Immunology, Medical School, University of Crete
- Bernard K. van der Veer
- KU Leuven, Department of Development and Regeneration, Stem Cell Institute
- Adrian Janiszewski
- KU Leuven, Department of Development and Regeneration, Stem Cell Institute
- Tijs Vanhessche
- KU Leuven, Department of Development and Regeneration, Stem Cell Institute
- Annick Francis
- Department of Cardiovascular Sciences, KU Leuven
- Youssef El Laithy
- KU Leuven, Department of Development and Regeneration, Stem Cell Institute
- Antonio Lo Nigro
- KU Leuven, Department of Development and Regeneration, Stem Cell Institute
- Francesco Aulicino
- Centre for Genomic Regulation (CRG), Dr Aiguader 88
- Kian Peng Koh
- KU Leuven, Department of Development and Regeneration, Stem Cell Institute
- Vincent Pasque
- KU Leuven, Department of Development and Regeneration, Stem Cell Institute
- Maria Pia Cosma
- Centre for Genomic Regulation (CRG), Dr Aiguader 88
- Catherine Verfaillie
- KU Leuven, Department of Development and Regeneration, Stem Cell Institute
- An Zwijsen
- Department of Cardiovascular Sciences, KU Leuven
- Björn Heindryckx
- Ghent-Fertility And Stem cell Team (G-FaST), Department for Reproductive Medicine, Department for Human Structure and Repair, Ghent University Hospital
- Christoforos Nikolaou
- Computational Genomics Group, Institute of Bioinnovation, Biomedical Sciences Research Center “Alexander Fleming”
- Frederic Lluis
- KU Leuven, Department of Development and Regeneration, Stem Cell Institute
- DOI
- https://doi.org/10.1038/s41467-023-36914-1
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 19
Abstract
Signal transduction and gene expression regulation via downstream transcription factors shape the early mammalian embryo. Here the authors show that Wnt/TCF7L1 transcriptional repressive activity is required for primitive endoderm lineage formation.
