Generality Assessment of a Model Considering Heterogeneous Cancer Cells for Predicting Tumor Control Probability for Stereotactic Body Radiation Therapy Against Non-Small Cell Lung Cancer

Ryo Saga, PhD; Yusuke Matsuya, PhD; Hideki Obara, PhD; Fumio Komai, MS; Hironori Yoshino, PhD; Masahiko Aoki, PhD, MD; Yoichiro Hosokawa, PhD, DDS

Advances in Radiation Oncology (Apr 2024)

Generality Assessment of a Model Considering Heterogeneous Cancer Cells for Predicting Tumor Control Probability for Stereotactic Body Radiation Therapy Against Non-Small Cell Lung Cancer

Ryo Saga, PhD,
Yusuke Matsuya, PhD,
Hideki Obara, PhD,
Fumio Komai, MS,
Hironori Yoshino, PhD,
Masahiko Aoki, PhD, MD,
Yoichiro Hosokawa, PhD, DDS

Affiliations

Ryo Saga, PhD: Department of Radiation Science, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan; Corresponding author: Ryo Saga, PhD.
Yusuke Matsuya, PhD: Nuclear Science and Engineering Center, Research Group for Radiation Transport Analysis, Japan Atomic Energy Agency, Tokai, Japan; Faculty of Health Sciences, Hokkaido University, Sapporo, Japan
Hideki Obara, PhD: Department of Radiology, Division of Medical Technology, Hirosaki University School of Medicine and Hospital, Hirosaki, Japan
Fumio Komai, MS: Department of Radiology, Division of Medical Technology, Hirosaki University School of Medicine and Hospital, Hirosaki, Japan
Hironori Yoshino, PhD: Department of Radiation Science, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan
Masahiko Aoki, PhD, MD: Department of Radiation Oncology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
Yoichiro Hosokawa, PhD, DDS: Department of Radiation Science, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan

Journal volume & issue: Vol. 9, no. 4
p. 101437

Abstract

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The generality of a model for predicting tumor control probability from in vitro clonogenic survival considering of cancer stem-like cells, the so-called integrated microdosimetric-kinetic model, is presented by comparing the model to public data on stereotactic body radiation therapy for non-small cell lung cancer cells.

Published in Advances in Radiation Oncology

ISSN: 2452-1094 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.journals.elsevier.com/advances-in-radiation-oncology/

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