Nature Communications (Jul 2018)
Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis
- Tamara Muliaditan,
- Jonathan Caron,
- Mary Okesola,
- James W. Opzoomer,
- Paris Kosti,
- Mirella Georgouli,
- Peter Gordon,
- Sharanpreet Lall,
- Desislava M. Kuzeva,
- Luisa Pedro,
- Jacqueline D. Shields,
- Cheryl E. Gillett,
- Sandra S. Diebold,
- Victoria Sanz-Moreno,
- Tony Ng,
- Esther Hoste,
- James N. Arnold
Affiliations
- Tamara Muliaditan
- School of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s Campus
- Jonathan Caron
- School of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s Campus
- Mary Okesola
- School of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s Campus
- James W. Opzoomer
- School of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s Campus
- Paris Kosti
- School of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s Campus
- Mirella Georgouli
- Tumour Plasticity Laboratory, Randall Centre for Cell and Molecular Biophysics, King′s College London, Guy′s Campus
- Peter Gordon
- School of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s Campus
- Sharanpreet Lall
- School of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s Campus
- Desislava M. Kuzeva
- School of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s Campus
- Luisa Pedro
- Medical Research Council Cancer Cell Unit, Hutchison/Medical Research Council Research Centre
- Jacqueline D. Shields
- Medical Research Council Cancer Cell Unit, Hutchison/Medical Research Council Research Centre
- Cheryl E. Gillett
- School of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s Campus
- Sandra S. Diebold
- National Institute for Biological Standards and Control
- Victoria Sanz-Moreno
- Tumour Plasticity Laboratory, Randall Centre for Cell and Molecular Biophysics, King′s College London, Guy′s Campus
- Tony Ng
- School of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s Campus
- Esther Hoste
- Unit for Cellular and Molecular Pathophysiology, VIB Center for Inflammation Research
- James N. Arnold
- School of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s Campus
- DOI
- https://doi.org/10.1038/s41467-018-05346-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
The relationship between wound healing and cancer is intricate and complex. Here, the authors show that in breast cancer models an IL-6 driven co-expression of FAP and HO-1 in tumour-associated macrophages, similar to the wound healing response, facilitates migration and metastatic spread.
