miRNA26 Expression in Plasma- A Potential Biomarker for the Diagnosis of Parkinson’s Disease

Abstract

Parkinson’s Disease (PD) is a chronic, progressive neurodegenerative disease characterised by both motor and non motor features. The diagnosis of PD is based on clinical evaluation, patient’s signs and symptoms, neurological and physical examinations. No diagnostic tests have been devised so far that can conclusively diagnose PD. So, the review aimed to assess the role of a minimally invasive biomarker for the early diagnosis of PD. Circulating microRibonucleic Acid (miRNA) could be the promising biomarker for PD. miRNA expression could be a useful marker for the diagnosis of PD. Early diagnosis may help in improving quality of life of patients with PD. Correlation of miRNA with disease severity may be useful in predicting the response to therapy as well as prognosis of the disease.

Keywords

• alternative marker
• neurodegenerative disorder
• prognosis