Fever of unknown origin successfully treated by oren-gedoku-to (huanglian-jie-du-tang)

Abstract

Koichiro Tanaka,1 Kazuhiko Nara,1 Tetsuya Nishimura,1 Keiko Serizawa,1 Taito Miyazaki,2 Yoshihisa Urita,2 Oto Miura11Division of Traditional Japanese Medicine, Department of General Medicine and Emergency Care, Faculty of Medicine, Toho University, 2Department of General Medicine and Emergency Care, Faculty of Medicine, Toho University, Tokyo, JapanAbstract: Oren-gedoku-to is a traditional medicine used for treating inflammatory conditions and is given by prescription in Japan, People's Republic of China, and Korea. Its anti-inflammatory effect is related to the arachidonate cascade and inhibition of cyclo-oxygenase, but research on other anti-inflammatory pathways is ongoing. We report a case of fever of unknown origin in a 33-year-old woman. The possibility of infection due to human immunodeficiency virus, autoimmune, neoplastic, or other disease was examined and excluded. Oren-gedoku-to was successfully used to treat her symptoms and may thus be a suitable treatment for patients with undiagnosed fever of unknown origin.Keywords: fever of unknown origin, oren-gedoku-to, huanglian-jie-du-tang, kampo