Risk factors for the relapses development of respiratory organs tuberculosis with a drug-resistant pathogen form

Abstract

Objectives. To analyze the significance of age, sex, social and medical risk factors for the relapses development of respiratory tuberculosis with a drug-resistant form of the causative agent. Material and methods. A retrospective analysis of 190 medical cards of inpatients over the past 5 years treated in the health care institution “Bogushevskaya Regional Tuberculosis Hospital” was carried out. Such indicators as age, sex, social and medical risk factors influencing the development of respiratory tuberculosis were analyzed. Results. Among these medical histories there were 172 of male patients, which made up 90.5%, and 18 of female patients (9.5%). The age of male patients suffering from recurrent respiratory tuberculosis (RT) was from 40 to 59 years, while that of women more frequently averaged from 30 to 39. People from rural areas had tuberculosis more often compared to urban residents. The analysis of the educational level showed that RT relapse was more common in those who had secondary and general secondary education and accounted for 65.8% of the entire sample. Among them 64% of persons were neither in registered nor in civil marriage. In women this index made up 66.6%. The body mass index (BMI) of patients was below the norm (<18.5) in 39.5% of the subjects studied. Normal BMI (18.5- <25) was registered in 55.2% and 5.3% of the patients were obese. Infiltrative forms dominated in the clinical structure of pulmonary tuberculosis relapses (79.5%), disseminated tuberculosis occurred in 11.5% of cases, while fibrous-cavernous tuberculosis was revealed only in 4.7% of patients. Conclusions. Thus, the greatest impact on the risk of developing relapses of RT with a drug-resistant form of the causative agent is exerted by the lack of work and family, low educational level and residence in places with underdeveloped infrastructure and the presence of harmful factors in the environment; the significance of the influence of age, profession, as well as nutritional status is slightly lower.

Keywords

• tuberculosis
• tuberculosis mycobacterium
• drug resistance
• relapse
• socio-economic factors
• nutritional status